Publication list of AN-PING ZENG
A. Peer reviewed Papers and book chapters
2011
164. Xue X, Li J, Wang W, Sztajer H, Wagner-Doebler I. (2011) The global impact of the delta subunit RpoE of the RNA polymerase on the proteome of Streptococcus mutans. Microbiology. 2011 Oct 13. [Epub ahead of print]
163. A. Chatzifragkou, G. Aggelis, M.Komaitis, A.-P. Zeng, S. Papanikolaou (2011). Impact of anaerobiosis strategy and bioreactor geometry on the biochemical response of Clostridium butyricum VPI 1718 during 1,3-propanediol fermentation. Bioresource Technology (in print).
162. M. Wurm and A.-P. Zeng (2011). Estimation of protein and metabolite release rates from damaged mammalian cells by using GFP as a marker molecule (submitted)
161. Uwe Jandt, Oscar Platas Barradas, Ralf Pörtner, and A.-P. Zeng (2011). Regulation and modelling of the pyruvate dehydrogenase complex in a mammalian cell line. (submitted)
160. M. Wurm and A.-P. Zeng (2011). Mechanical disruption of mammalian cells in a microfluidic system and its numerical analysis based on computational fluid dynamics (submitted)
159. Chengwei Ma, Zhilong Xiu, A.-P. Zeng (2011). Discovery of Intramolecular Signal Transduction Network Based on a New Protein Dynamics Model of Energy Dissipation (submitted)
158. Chengwei Ma, Zhilong Xiu, A.-P. Zeng (2011). A New Concept to Reveal Protein Dynamics Based on Energy Dissipation. PLOS ONE 6(10): e26453. doi:10.1371/journal.pone.0026453
157. Sercinoglu, O., Platas Barradas, O., Sandig, V., A.-P. Zeng, Pörtner, R. 2011). DoE of fed-batch processes - model-based design and experimental evaluation.BMC Proceedings 2011, 5(Suppl 8):P46
156. Platas Barradas, O., Jandt, U., Phan, L.D.M., Villanueva, M., Rath, A., Reichl, U., Schräder, E., Scholz, S., Noll, T., Sandig, V., Pörtner, R., A.-P. Zeng (2011). Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture. BMC Proceedings 2011, 5(Suppl 8):P47
155. Schaletzky, M., Platas Barradas, O., Sievert, H., Balabanov, S., A.-P. Zeng, Pörtner, R. (2011). Cultivation strategies of a BA/F3 cell line for fundamental cell research.BMC Proceedings 2011, 5(Suppl 8):P48
154. Platas Barradas, O., Jandt, U., Hass, R., Kasper, C., Sandig, V., Pörtner, R., A.-P. Zeng (2011). Physical methods for synchronization of a human production cell line. BMC Proceedings 2011, 5(Suppl 8):P49
153. U. Jandt and A.-P. Zeng (2011). Modeling of intracellular transport and compartmentation. In Adv. Biochem. Eng. Biotechnol: "Genomics and Systems Biology of Mammalian Cell Culture" Volume Editors: A.-P. Zeng and W.-H. Hu (In print).
152. L. Song, P. Sudhakar, W. Wang, G. Conrads, A. Brock, J. Sun, I. Wagner-Döbler, A.-P. Zeng (2011) A genome-wide study of two-component signal transduction systems in eight newly sequenced mutans streptococci strains. BMC Genomics (under revision).
151. Platas Barradas, O., Pörtner, R., Jandt, U., Phan, L.D.M., Villanueva, M.E., Rath, A., Reichl, U., Schräder, E., Scholz, S. , Noll, T., Sandig, V., A.-P. Zeng (2011) Evaluation of criteria for bioreactor comparison and operation standardisation for mammalian cell culture. (submitted).
150. Michael Stelzer, Jibin Sun, A.-P. Zeng, Tom Kamphans, and Sándor Fekete (2011). An extended bioreaction database that significantly improves reconstruction and analysis of genome-scale metabolic networks. Integrative Biology. DOI: 10.1039/C1IB00008J
149. Rosarin Rujananona, Poonsuk Prasertsana, Amornrat Phongdarab, Tanate Panratb, Jibin Sun, Sugima Rappert, A.-P. Zeng (2011) Construction of recombinant E.coli expressing fusion protein to produce 1,3-propanediol. International Journal of Biological and Medical Sciences 1:1,2011.
148. M. Metsoviti, S. Paramithiotis, E. H. Drosinos, M. Galiotou-Panayotou, G.J. Nychas, A.-P. Zeng, S. Papanikolaou (2011) Screening of bacterial strains capable of converting biodiesel derived raw glycerol into 1,3-propanediol, 2,3-butanediol and ethanol. Life Sci. Eng. (in print).
147. A.-P. Zeng (2011) New biotechnological production systems (meeting report). Biotechnol. J.
146. Hong-Wu Ma, A.-P. Zeng and Igor Goryanin (2011) KNEVA: A web tool for KEGG based metabolic networks reconstruction, analysis and visualization.Nuc. Acid Res. (Submitted).
145. Zhen Chen, Sugima Rappert, Jibin Sun and A.-P. Zeng (2011) Integrating molecular dynamics and co-evolutionary analysis for reliable target prediction and deregulation of the allosteric inhibition of aspartokinase for amino acid production. J. Biotechnol. (in print)
144. Zhen Chen, Weiqian Meyer, Sugima Rappert, Jibin Sun and A.-P. Zeng (2011) Co-evolutionary analysis enables rational deregulation of allosteric enzyme inhibition in Corynebacterium glutamicum for lysine production. Appl. Env. Microbiol. (accepted)
143. Bo Yu, Jibin Sun, Rajesh Reddy Bommareddy, Lifu Song, A.-P. Zeng (2011) A novel (2R,3R)-2,3-Butanediol Dehydrogenase from an Industrially Potential Strain Paenibacillus polymyxa ATCC12321. Appl. Environ. Microbiol.June 2011.77(12):4230-4233
142. Uwe Jandt, Shi Shao, Manfred Wirth and A.-P. Zeng (2011) Spatiotemporal modeling and analysis of transient gene deliveryBiotech Bioeng, 108(9):2205-2217.
141. Hong-Wu Ma, A.-P. Zeng (2011) Modularity based Network Decomposition (under revision)
140. Hong-Wu Ma, A.-P. Zeng (2011) Network decomposition: methods for identifying modules in complex biological networks (under revision)
139. A.-P. Zeng and Wael Sabra (2011) Microbial production of diols as platform chemicals: recent progresses. Curr. Opinion in Biotechnology. 22: 749-757.
138. Afroditi Chatzifragkou, Seraphim Papanikolaou, Agapi I. Doulgeraki, George-John E. Nychas and A.-P. Zeng (2011) Production of 1,3-propanediol by Clostridium butyricum growing on biodiesel-derived crude glycerol through a non-sterilized fermentation process. Appl. Microbial. Biotechnol. 91,101-112.
137. Wael Sabra, Jian-Ying Dai, Hendrich Quitmann, An-Ping Zeng and Zhi-Long Xiu (2011) Microbial production of 2, 3-butanediol. In: Comprehensive Biotechnology. Second edition, Vol. 3: Industrial Biotechnology and Commodity Products. Eds. Moreina and Bai. 87-97.
136. T. Kaeding, D. Tjahjasari and A.-P. Zeng (2011) 1,3-Propanediol and Polytrimethyleneterephthalate. In: Comprehensive Biotechnology. Vol. 3: Industrial Biotechnology and Commodity Products (eds. Moreina and Bai), 229-242.
2010
135. A.-P. Zeng (2010) From Systems Biology to biosystems engineering (Editorial). Engineering in Life Sciences, 10, 380-381.
134. Wael Sabra, David Dietz, Donna Tjahjasari and A.-P. Zeng (2010) Biosystems analysis and engineering of microbial consortia for industrial biotechnology. Engineering in Life Sciences, 10, 407-421.
133. Zhen Chen, Matthias Wilmanns and A.-P. Zeng (2010) Structural synthetic biotechnology: from molecular structure to predictable design of cellular processes for industrial strain development. Trends in Biotechnology. 28, 534-542.
132. Xin Lu, Jibin Sun, Manfred Nimtz, Josef Wissing, A.-P. Zeng and Ursula Rinas (2010). The proteome of Aspergillus niger growing on synthetic medium with xylose or maltose as carbon source. Microbial Cell Factories 2010, 9:23.
131. Afroditi Chatzifragkou, David Dietz, Michael Komaitis, A.-P. Zeng and Seraphim Papanikolaou (2010). Effect of biodiesel-derived waste glycerol impurities on biomass and 1,3-propanediol production of Clostridium butyricum VPI 1718. Biotechnol. Bioeng. 107, 76-84.
130. M. Wurm, B. Schöpke, D. Lutz and A.-P. Zeng (2010). Microtechnology meets systems biology: The small molecules of metabolome as next big targets. J. Biotechnol. 149,33-51.
129. R. Grote, B. Schöpke, A.-P. Zeng and G. Antranikian (2010) Biotransformationsreaktionen in Mikrosystemtechnik - Visionen für die Industrielle Biotechnik. In: "Nach uns, ohne Öl: Auf dem Weg zu nachhaltiger Produktion" M. Angrick (Ed.),Metropolis-Verlag, Marburg. Pp.129-141.
128. Özlem Aydogan, Emine Bayraktar, Ülkü Mehmeto?lu, Thomas Kaeding and A.-P. Zeng. Selection and Optimization of an Aqueous Two-Phase System for the Recovery of 1,3-Propandiol from Fermentation Broth. Engineering in Life Sciences, 10: 121-129.
127. M. Marcin Bizukojc, David Dietz, Jibin Sun, A.-P. Zeng (2010). Metabolic modelling of syntrophic-like growth of a 1,3-propanediol producer Clostridium butyricum and a methanogenic archeon Methanosarcina mazei under anaerobic conditions. Bioprocess and Biosyst. Eng. 33:507-523.
2009
126. Feng He, Rudi Balling^, A.-P. Zeng (2009) Reverse engineering and verification of gene networks: Principles, assumptions and limitations of present methods and future perspectives. . Biotechnol. 144, 190-203.
125. A.-P. Zeng and J. Sun. (2009) Continuous culture. In: Manual of Industrial Microbiology and Biotechnology. In: Manual of Industrial Microbiology and Biotechnology. 3nd. edition, R.H. Baltz, J.E. Davies and A. L. Demain (Eds.), American Society for Microbiology, Washington, D.C. pp. 685-699.
124. M. Flipphi, J. Sun, X. Robellet. L. Karaffa, E. Fekete, A.-P. Zeng, C. P. Kubicek (2009) Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp. Fungal Genetics and Biology 46, 19 - 44.
123. W. Sabra and A.-P. Zeng (2009). Microbial production of alginates: Physiology and process aspects. In B. H.A. Rehm (Ed.) Alginates: Biology and Applications. Springer-Verlag. 153-175.
2008
122. Y.-H. Liu, J.-X. Bi, A.-P. Zeng, J.-Q. Yuan (2008). A cybernetic model to describe the dynamics of myeloma cell cultivations. Applied Mathematics and Computation. 205:84-97. PDF
121. L. Hilterhaus, B. Minow, J. Müller, M. Berheide, H. Quitmann, M. Katzer, G. Antranikian, A.-P. Zeng, A. Liese (2008) Practical application of different enzymes immobilized on sepabeads. Bioprocess Biosyst Eng. 31(3):163-71. PDF , Pubmed
120. J. Sun and A.-P. Zeng (2008) Systems Biotechnology. In: 2008 Report on the Development of Industrial Biotechnology. Ed. The Bureau of Life Science & Biotechnology, Chinese Academy of Sciences, Science Press, Beijing.
119. Z.-L. Xiu and A.-P. Zeng (2008). Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol. Appl Microbiol Biotechnol. 78(6):917-26. PDF, Pubmed
118. M.R. da Silva, H. Ma, A-P. Zeng (2008). Centrality, Network Capacity, and Modularity as Parameters to Analyze the Core-Periphery Structure in Metabolic Networks. Proceedings of the IEEE 96(8): 1411-1420. PDF
117. Y.-H. Liu, J.-X. Bi, A.-P. Zeng, J.-Q. Yuan (2008). A simple kinetic model for myeloma cell culture with consideration of lysine limitation. Bioprocess Biosyst Eng. 31(6):569-77. PDF
116. Q. Zhang, H. Teng, Y. Sun, Z. Xiu, A.-P. Zeng (2008) Metabolic flux and robustness analysis of glycerol metabolism in Klebsiella pneumoniae. Bioprocess Biosyst Eng. 1(2):127-35. PDF
2007
115. Y.-H. Liu, J.-X. Bi, A.-P. Zeng, J.-Q. Yuan (2007). A population balance model describing the cell cycle dynamics of myeloma cell cultivation. Biotechnol. Prog. 23:1198-1209. , Pubmed
114. C. Ulmer and A.-P. Zeng (2007). Microbial production of 3-hydroxypropionaldehyde from glycerol bioconversion. Chem. Biochem. Eng. Q. 21; 321-326. PDF
113. P. Zheng, J Sun, R. Geffers, A.-P. Zeng (2007) Functional characterization of the gene PA2384 in large scale gene regulation in response to iron starvation in Pseudomonas aeruginosa. J. Biotechnol. 132: 342-352. PDF
112. Pel,H.J., de Winde,J.H., Archer,D.B., Dyer,P.S., Hofmann,G., Schaap,P.J., Turner,G., de Vries,R.P., Albang,R., Albermann,K., Andersen,M.R., Bendtsen,J.D., Benen,J.A., van den,B.M., Breestraat,S., Caddick,M.X., Contreras,R., Cornell,M., Coutinho,P.M., Danchin,E.G., Debets,A.J., Dekker,P., van Dijck,P.W., van Dijk,A., Dijkhuizen,L., Driessen,A.J., d'Enfert,C., Geysens,S., Goosen,C., Groot,G.S., de Groot,P.W., Guillemette,T., Henrissat,B., Herweijer,M., van den Hombergh,J.P., van den Hondel,C.A., van der Heijden,R.T., van der Kaaij,R.M., Klis,F.M., Kools,H.J., Kubicek,C.P., van Kuyk,P.A., Lauber,J., Lu,X., van der Maarel,M.J., Meulenberg,R., Menke,H., Mortimer,M.A., Nielsen,J., Oliver,S.G., Olsthoorn,M., Pal,K., van Peij,N.N., Ram,A.F., Rinas,U., Roubos,J.A., Sagt,C.M., Schmoll,M., Sun,J., Ussery,D., Varga,J., Vervecken,W., van de Vondervoort,P.J., Wedler,H., Wosten,H.A., A.-P. Zeng, van Ooyen,A.J., Visser,J., Stam,H. (2007) Genome sequence and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nature Biotechnol. 25: 221-231. PDF , supplementary materials
111 F. He, J. Buer, A.-P. Zeng, R. Balling (2007) Dynamic cumulative activity of transcription factors as a mechanism of quantitative gene regulation in multi-regulator transcriptional regulatory motifs. Genome Biology 2007, 8:R181. PDF , Journal
110 J. Sun, X. Liu, U. Rinas and A.-P. Zeng (2007) Metabolic pecularities of Aspergillus niger disclosed by comparative metabolic genomics. Genome Biology 2007, 8:R182. PDF , Journal
109. M.R. da Silva, H. Ma, J.Sun, F. He, A.-P. Zeng (2006) Metabolic network. In B. H. Junker, F. Schreiber (eds.) Biological Network Analysis, Wiley: 233-253.
108. B. Ma, F. He, J. Jablonska, S. Winkelbach, W. Lindenmaier, A.-P. Zeng, and K. Dittmar. A system approach for six-colour segmentation analysis of multi-colour images in the infection studies of Listeria monocytogenes. Microscopy Research & Technique. 2007, 70 (2):171-178. PDF
107. Ma H., Rosa da Silva M., Sun J., Kumar B., A.-P. Zeng (2007) Reconstruction and Structural Analysis of Metabolic and Regulatory Networks. In: "Introduction to Systems Biology". Eds. Sangdun Choi, Humana Press.
106. Zhou F, Bi JX, Zeng AP, Yuan JQ. Macrokinetic model for myeloma cell culture based on stoichiometric balance. Biotechnol Appl Biochem. PDF
105. Y. Li, J. Bi, W. Zhou, Y. Huang, L. Sun, A.-P. Zeng, G. Ma, Z. Su. (2007) Characterization of the large size aggregation of Hepatitis B virus surface antigen (HBsAg) formed in ultrafiltration process. Process Biochemistry. 42: 315-319. PDF
PDF2006
104. Q. Zhang, Z.-L. Xiu and A.-P. Zeng (2006) Optimization of microbial production of 1,3-propanediol by Klebsiella pneumoniae under anaerobic and microaerobic conditions by metabolic flux analysis. J. Chem. Ind. Eng. 57, 1403-1409.
103. W. Wang, J. Sun, R. Homann, A.-P. Zeng and W-d. Deckwer (2006) Proteomic characterization of transient expression and secretion of a stress-related metalloprotease in high cell density culture of Bacillus megaterium. J. Biotechnology 126: 313-324. PDF
102. Zheng P, Sun J, van den Heuvel J, Zeng AP. Discovery and investigation of a new, second triose phosphate isomerase in Klebsiella pneumoniae. J Biotechnol. 2006. 125(4):462-473. PDF
101. Zeng AP. Editorial. Process Biochemistry (Special Issue: From Biochemical Engineering to Systems Biology - In honour of Dr. Wolf-Dieter Deckwer). 2006. 41(10):2101-2102 PDF
100. Zheng P, Wereath K, Sun J, van den Heuvel J and A.-P. Zeng. Overexpression of genes of the dha regulon and its effects on cell growth, glycerol fermentation to 1,3-propanediol and plasmid stability in Klebsiella pneumoniae. Process Biochemistry. 2006. 41(10):2160-2169 PDF
99. Zhou F, Bi J, Zeng AP and Yuan J. A macrokinetic and regulator model for myeloma cell culture based on metabolic balance of pathways. Process Biochemistry. 2006. 41(10):2207-2217. PDF
98. J. Sun, W. Wang, C. Hundertmark, A.-P. Zeng, D. Jahn and W.-D. Deckwer (2006) A protein database constructed from low-coverage genomic sequence of Bacillus megaterium and its use for accelerated proteomic analysis.J. Biotechnol. 124(3):486-95. PDF
97. W.-D. Deckwer, D. Jahn, D. Hempel, A.-P. Zeng (2006) System Biology Approach to Bioprocess Development. Life Science Eng. 6: 455-469. PDF
96. W.-D. Deckwer, D. Jahn, A.-P. Zeng, D. Hempel (2006) Systembiologische Ansätze zur Prozessentwicklung. Chem. Ing. Tech. 78, 193-207. PDF
95. F. He and A.-P. Zeng (2006) In search of functional association of genes from time-series microarry expression data by a new method based on change trend and expression levels of genes. BMC Bioinformatics 7:69. PDF
2005
94. Jan Buer, Astrid M. Westendorf, A.-P. Zeng, Wiebke Hansen & Michael Probst-Kepper (2005) Mechanisms of central and peripheral T cell tolerance: An update. Transfus Med Hemother. 32: (DOI:10.1159/000089128)
93. Zhang F., Bi J.X., A.-P. Zeng, Yuan J.Q. (2005) A simple kinetic model for myeloma cell growth with lysin as a limiting substrate. J. of Shanghai Jiaotong University . 139, 182-186.
92. A.-P. Zeng and J. Bi (2005) Cell Culture Kinetics and Modeling. In: S.S. Ozturk and W.-S. Hu (eds.) Cell Culture Technology for Pharmaceutical and Cellular Therapies. Taylor & Francis Group, Atlanta . pp: 299-347.
91. B. Kumar, H. Ma and A.-P. Zeng (2005) An integrated cellular network of Escherichia coli and its structural analysis. Proceedings of Foundation of Systems Biology in Engineering. University of California , Santa Babara , USA , August 7-10. pp 107-110.
90. H. Ma, A.-P. Zeng (2005) Reconstruction of metabolic network from genome information and its structural and functional analysis. In: R. Eils and A. Kriete (Eds.) Computational Systems Biology, Elsevier Inc., USA . Pp: 169-189.
89. Sun J, Gunzer F, Buer J, Gößling F, Scharfe M, Blöcker H and A.-P. Zeng (2005). Genomic peculiarity of coding sequences and metabolic potential of the probiotic Escherichia coli strain Nissle 1917 inferred from raw genome sequence. J. Biotechnol. 117 (2): 147-161. PDF
88. A.-P. Zeng, J. Sun, W. Wang, H. Ma and W.-D. Deckwer (2005) Application of genomic and proteomic data for bioprocess analysis and optimisation. In S.T. Yang (ed.) Bioprocessing for value-added products from renewable resources. Elservier Inc, USA. Pp: 25-48.
87. E.-J. Kim, W.-D. Deckwer, W. Wang and A.-P. Zeng (2005) Expression of the quorum sensing regulator protein LasR of is strongly affected by iron deficiency and oxygen concentration in Pseudomonas aeruginosa irrespective of cell density. Microbiology, 151: 1127-1138.
2004
86. H. Ma, B. Kumar, U. Ditges, Gunzer F, J. Buerand, A.-P. Zeng (2004) An extended transcriptional regulatory network of Escherichia coli and analysis of its hierarchical structure and network motifs. Nucleic Acids Res. 32: 6643-6649.
85. H. Ma, J. Buer and A.-P. Zeng (2004) Hierarchical structure and modules in the Escherichia coli transcriptional regulatory network revealed by a new top-down approach . BMC Bioinformatcs, 5:199.
84. J. Sun, R. Daniel, I. Wagner-Döbler and A.-P. Zeng (2004) Is autoinducer-2 a universal signal for interspecies communication? A comparative and phylogenetic genomic analysis of the synthesis and signal transduction pathways. BMC Evolutionary Biology, 4:36. PDF, Journal
83. J Sun and A.-P. Zeng (2004) Identics - Identification of coding sequences and in silico reconstruction of the metabolic network directly from unannotated low-coverage bacterial genome sequences. BMC Bioinformatics, 5:112. PDF
82 U Ditges, M Hartmann, S Coldewey, HW Ma, A.-P. Zeng, F Gunzer (2004) Acid resistance in enterohemorrhagic E-coli: Is there a link to the serotype ? International Journal of Medical Microbiology 294:161-161 Suppl. 39.
81. H. Ma, X.-M. Zhao, Y-J. Yuan and A.-P. Zeng (2004) Decomposition of metabolic network into functional modules based on the global connectivity structure of reaction graph. Bioinformatics. 20: 1870-1876.
80. H. Ma and A.-P. Zeng (2004) Phylogenetic comparasion of metabolic capacities of organisms at genome level. Molecular Phylogenetics and Evolution. 31, 204-213.
79. F. He, H. Ma, X.-M. Zhao, Y.-J. Yuan, A.-P. Zeng (2004) Progress and perspective in the application of bioinformatics for the analysis of metabolic networks . J. Chem. Ind. Eng. ( Chinese). 55:1593-1601.
78. A.-P. Zeng and E.-J. Kim (2004) Iron availability, oxygen limitation, Pseudomonas aeruginosa and cystic fibrosis. Microbiology. 150: 516-518.
77. Z.-L. Xiu, B.-H. Song, Z.-T. Wang, L.-H. Sun, E.-M. Feng and A.-P. Zeng (2004) Optimization of dissimilation of glycerol to 1,3-propanediol by Klebsiella pneumoniae in one- and two-stage anaerobic cultures . Biochem. J., 19: 189–197.
2003
76. H. Ma and A.-P. Zeng (2003) The connectivity structure, giant strong component and centrality of metabolic networks. Bioinformatics. 19: 1423-1430. PDF , supplementary material
75. H. Ma and A.-P. Zeng (2003) Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms. Bioinformatics. 19: 270-277. PDF , supplementary material , database
74. W. Wang, J. Sun, M. Nimtz, W.-D. Deckwer and A.-P. Zeng (2003) Protein identification from 2-dimentional gel electrophoresis analysis of Klebsiella pneumoniae by combined use of mass spectrometry data and unannotated genome sequences. Proteome Science. 1, 6. PDF
73. J. Sun, J. van den Heuvel, P. Soucaille and A.-P. Zeng (2003) Comparative genomic analysis of dha regulon and related genes for anaerobic glycerol metabolism in microorganisms. Biotechnol. Prog. 19: 263-272. PDF
72. W. Wang, J. Sun, M. Hartlep, W.-D. Deckwer and A.-P. Zeng. (2003) Combined use of proteomic analysis and enzyme activity assay for metabolic pathway analysis of glycerol fermentation by Klebsiella pneumoniae . Biotechnol. Bioeng. 83: 525-536. PDF
71. J.-J. Qiao, Y.-J. Yuan, H. Zhao1, J.-C. Wu and A.-P. Zeng (2003) Apoptotic cell death in suspension cultures of Taxus cuspidata co-treated with salicylic acid and hydrogen peroxide. Biotechnology Letters 25: 387–390.
70. Qiao JJ, Zhao H, Ge ZQ, Yuan YJ, A.-P. Zeng (2003).
2-dimensional gel electrophoresis on protein patterns from suspension cultures
of Taxus cuspidate induced by SA.
Chinese Journal of Biotechnology. 19(1):
92-96.
69. E.-J. Kim, W. Sabra, A.-P. Zeng (2003) Iron deficiency leads to inhibition of oxygen transfer and enhanced formation of virulence factors in Pseudomonas aeruginosa cultures. Microbiology 149, 2627-2634.
68. J.-X. Bi, P. Buhr, A.-P. Zeng and M. Wirth (2003) The Human c-fos Promoter Mediates High-level, Inducible Expression in Various Mammalian Cell Lines . Biotechnol. Bioeng. 81: 845-854.
67. W. Sabra, H. Lünsdorf and A.-P. Zeng (2003) Alterations in the formation of lipopolysaccharide and membrane vesicle on the surface of Pseudomonas aeruginosa PAO1 under oxidative stress conditions . Microbiology. 149, 2789-2795.
2002
66. J. Bi, M. Wirth, C. Beer, E.-J. Kim and A.-P. Zeng (2002) Dynamic characterization of recombinant Chinese Hamster Ovary cells containing an inducible c-fos promoter GFP expression system as a biomarker. J. Biotechnol. 93: 231-242.
65. A.-P. Zeng and H. Biebl (2002) Bulk-Chemicals from Biotechnology: the case of microbial production of 1,3-propanediol and the new trends. In K. Schügerl and A.-P. Zeng (Eds.) Tools and Applications of Biochemical Engineering Science. Adv. Biochem. Eng. Biotechnol. Vol. 74: 237-257.
64. Z.-Y. Ma; Y.-J. Yuan; J.-C. Wu and A.-P. Zeng (2002) Apoptotic cell death in suspension cultures of Taxus chinensis var. mairei. Biotechnol. Letters 24(7): 573-577.
63. Y.-J. Yuan, Z.-Y. Ma, J.-C. Wu and A.-P. Zeng (2002) Taxol-induced apoptotic cell death in suspension cultures of Taxus cuspidate. Biotechnol. Letters 24(8): 615-618.
62. Yuan, Y.-J., Li, C., Hu, Z.-D., J-C. Wu, Zeng, A.-P. (2002) Fungal Elicitor-Induced Cell Apoptosis in Suspension Cultures of Taxus chinensis var. mairei for Taxol Production. Process Biochem. 38: 193-198.
61. Xiu, Z.-L., Song , B.-H., Sun, L.-H. and Zeng, A.-P. (2002) Theoretical analysis of effects of metabolic overflow and time delay on the performance and dynamic behavior of a two-stage fermentation process. Biochemical Eng. J. 11, 101-109.
60. Xiu, Z.-L., Chang, Z.-Y. and Zeng, A.-P. (2002) Nonlinear dynamics of regulation of bacterial trp operon: model analysis of integrated effects of repression, feedback inhibition and attenuation. Biotechnol. Progress. 18. 686-693.
59. A.-P. Zeng, J. Modak and W.-D. Deckwer (2002) Nonlinear dynamics of eucaryotic pyruvate dehydrogenase multi-enzyme complex: Decarboxylation rate, oscillations and multiplicity. Biotechnol. Prog. 18: 1265-1276.
58. J. Modak, W.-D. Deckwer and A.-P. Zeng (2002) Metabolic control analysis of eucaryotic pyruvate dehydrogenase multi-enzyme complex. Biotechnol. Prog. 18: 1157-1169.
57. W. Sabra, E.J. Kim and A.-P. Zeng (2002) Physiological responses of Pseudomonas aeruginosa PAO1 to oxidative stress in controlled microaerobic and aerobic culture. Microbiology. 148: 3195-3202.
56. M. Hartlep, W. Hussmann, N. Prayitno , I. Meynial-Salles and A.-P. Zeng (2002) Study of two-stage processes for the microbial production of 1,3-propanediol from glucose. App. Microbial. Biotechnol. 60:60-66.
2001
55. Wael Sabra, A.-P. Zeng and W.-D. Deckwer (2001) Microbial alginates: physiology, quality and process aspects. Appl. Microbial. Biotechnol. 56: 315-325.
54. Yuan, Y.-J., Ma Z.Y., Ge Z.Q, Miao Z.Q., Zeng, A.-P. (2001) Apoptosis and taxol production in suspension cultures of Taxus spp. cells. J. Chem. Ind. Eng. 51, 43-46.
2000
53. Wael Sabra, A.-P. Zeng, H. Lünsdorf and W.-D. Deckwer (2000) Effect of Oxygen on the Formation and Structure of Azotobacter vinelandii Alginate and its Role in Protecting Nitrogenase. Appl. Environ. Microbiol. 66 (9): 4037-4044.
52. Z.-L. Xiu, A.-P. Zeng, L.J. An and W.-D. Deckwer (2000) Transient responses and mathematical modeling of Klebsiella pneumoniae to dilution rate and glycerol concentration step changes in continuous culture. J. Chemical Engineering of Chinese Universities. Vol. 14, No.1: 53-58.
51. A.-P. Zeng and M. Linz (2000) Programmed cell death (apoptosis) in animal cell culture: physiological and kinetic aspects. In: J.J. Zhong (ed.): Advances in Applied Biotechnology. ECUST Press, Shanghai . pp. 64-77.
1999
50. H. Biebl, K. Menzel, A.-P. Zeng and W.-D. Deckwer (1999) Microbial production of 1,3-propanediol. App. Microbiol. Biotechnol. 52: 289-297.
49. Z.-L. Xiu and A.-P. Zeng (1999) Progress in the study of oscillatory and chaotic behavior of microbial continuous culture. Biotechnology Progress. 19 (6): 58-63.
48. Z.-L. Xiu, W.-D. Deckwer and A.-P. Zeng (1999) Estimation of rates of oxygen consumption and carbon dioxide evolution of animal cell culture using material and energy balance. Cytotechnology. 15, 1-8.
47. A.-P. Zeng and W.-D. Deckwer (1999) Model simulation and analysis of perfusion cultures of animal cells at high cell density. Biotechnol. Prog. 15: 373-382.
46. Wael Sabra, A.-P. Zeng and W.-D. Deckwer (1999) Effects of phosphate and dissolved oxygen concentrations on alginate production and stoichiometry of metabolism of Azotobacter vinelandii in pO2-controlled microaerobic culture . Appl. Microbiol. Biotechnol. 52: 773-780.
45. S. Brandt, A.-P. Zeng and W.-D. Deckwer (1999) Adsorption capacity as a key parameter for enzyme induction and pentachlorophenol degradation in Mycobacterium chlorophenolicum PCP-1. Biotechnol. Bioeng. 65: 93-99.
44. A.-P. Zeng (1999) Continuous culture. In: Manual of Industrial Microbiology and Biotechnology. 2nd. edition, A. L. Demain and N. A. Solomon (Eds.), American Society for Microbiology, Washington, D.C. pp:151-164.
1998
43. Z.-L. Xiu, A.-P. Zeng and W.-D. Deckwer (1998) Multiplicity and stability analysis of microorganisms in continuous culture: Effect of metabolic overflow and growth inhibition. Biotechnol. Bioeng. 57: 251-261.
42. A.-P. Zeng, W.-D. Deckwer and W.-S. Hu (1998) Determinants and rate laws of growth and death of animal cells in continuous cultures. Biotechnol. Bioeng. 57: 642-654.
41. A.-P. Zeng, W.-S. Hu and W.-D. Deckwer (1998) Variation of stoichiometric ratios and their correlation for monitoring and control of animal cell cultures. Biotechnol. Prog. 14: 434-441.
40. A.-P. Zeng and W.-D. Deckwer (1998) Neue Ansätze zur Modellierung, regelung und Überwachung tierischer Zellkulturen. Chem.-Ing.-Tech. 70, 1127-1128.
39. K. Ahrens, K. Menzel, A.-P. Zeng and W.-D. Deckwer (1998) Kinetic, dynamic and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture. Part III: Enzymes and fluxes of glycerol dissimilation and 1,3-propanediol formation. Biotechnol. Bioeng. 59: 544-552.
38. K. Menzel, K. Ahrens, A.-P. Zeng and W.-D. Deckwer (1998). Kinetic, dynamic and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture. Part IV: Enzymes and fluxes of pyruvate metabolism. Biotechnol. Bioeng. 60:617-626.
37. H. Biebl, A.-P. Zeng, K. Menzel and W.-D. Deckwer (1998) Glycerol fermentation to 1,3-propanediol and 2,3-butanediol by Klebsiella pneumoniae. App. Microbiol. Biotechnol. 50: 24-29.
36. C. Wittmann, A.-P. Zeng and W.-D. Deckwer (1998) Physiological characterization and cultivation strategies of the pentachlorophenol degrading bacteria Sphingomonas chlorophenolica RA2 and Mycobacterium chlorophenolicum-PCP1. J. Ind. Microbiol. Biotechnol. 21, 315-321.
1997
35. K. Menzel, A.-P. Zeng and W.-D. Deckwer (1997) High concentration and productivity of 1,3-propanediol from continuous fermentation of glycerol by Klebsiella pneumoniae. Enzyme Microbiol. Technol. 20: 82-86.
34. K. Menzel, A.-P. Zeng and W.-D. Deckwer (1997) Enzymatic evidence of involvement of pyruvate dehydrogenase in anaerobic glycerol metabolism by Klebsiella pneumoniae. J. Biotechnol. 56: 135-142.
33. M. Linz, A.-P. Zeng, R. Wagner and W.-D. Deckwer (1997) Stoichiometry, kinetics, and regulation of glucose and amino acid metabolism of a recombinant BHK cell line in batch and continuous cultures. Biotechnol. Prog. 13: 453-463.
32. Z.-L. Xiu, A.-P. Zeng and W.-D. Deckwer (1997) Model analysis concerning effects of growth rate and intracellular tryptophan level on the stability and dynamics of tryptophan operon and tryptophan biosynthesis in bacteria. J. Biotechnol. 58: 125-140.
31. S. Brandt, A.-P. Zeng, and W.-D. Deckwer (1997) Adsorption and desorption of pentachlorophenol on cells of Mycobacterium chlorophenolicum. Biotechnol. Bioeng. 53: 480-489.
30. A.-P. Zeng, H. Biebl and W.-D. Deckwer (1997) Microbial conversion of glycerol to 1,3-propanediol - Recent progress. Chapter 14, pp 264 - 279 in: B. C. Saha and J. Woodward (eds.) Fuels and Chemicals from Biomass. ACS Symposium Series 666, American Chemical Society, Washinton , DC .
1996
29. A.-P. Zeng (1996) Analysis and mathematical modeling of monoclonal antibody production by hybridoma cells. Biotechol. Bioeng. 50, 238-247.
28. A.-P. Zeng (1996) Quantitative assessment of effect of cell density on metabolism and monoclonal antibody production of hybridoma cells. J. Biotechnol. 45, 243-251.
27. A.-P. Zeng and W.-D. Deckwer (1996) Bioreaction techniques under low oxygen tension and oxygen limitation: from molecular level to pilot plant reactor. Chem. Eng. Sci. 51: 2305-2314.
26. A.-P. Zeng (1996) Pathway and kinetic analysis of glycerol fermentation by Clostridium butyricum. Bioprocess Eng. 14, 169-175.
25. K. Menzel, A.-P. Zeng, H. Biebl and W.-D. Deckwer (1996) Kinetic, dynamic and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture. Part I: The phenomena and characterisation of oscillation and hysteresis. Biotechnol. Bioeng. 52, 549-560
24. A.-P. Zeng, K. Menzel and W.-D. Deckwer (1996) Kinetic, dynamic and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture. Part II: Analysis of metaboic fluxes and pathways under oscillation and steady-state conditions. Biotechnol. Bioeng. 52, 561-571.
1995
23. A.-P. Zeng (1995) A kinetic model for product formation of microbial and mammalian cells. Biotechnol. Bioeng. 46, 314-324.
22. A.-P. Zeng and W.-D. Deckwer (1995) Mathematical modeling and analysis of glucose and glutamine utilization and regulation in cultures of continuous mammalian cells. Biotechnol. Bioeng. 47, 334-346.
21. A.-P. Zeng and W.-D. Deckwer (1995) A kinetic model for substrate and energy consumption of microbial growth under substrate-sufficient conditions. Biotech. Prog. 11: 71-79.
20. A.-P. Zeng (1995) A new balance equation of reducing equivalents for data consistency check and calculations of bioprocesses. J. Biotechnol. 43: 111-124.
19. C. Wittmann, A.-P. Zeng and W.-D. Deckwer (1995) Growth inhibition by ammonium and the use of pH-controlled feeding for effective cultivation of Mycobacterium chlorophenolicus. Appl. Microbiol. Biotechnol. 44: 519-525.
18. B. O. Solomoon, A.-P. Zeng, H. Biebl, H .Schlieker, C. Posten and W.-D. Deckwer (1995) Comparison of the energetic efficiencies of hydrogen and oxychemicals formation in Klebsiella pneumoniae and some Clostridia during anaerobic growth on glycerol. J. Biotechnol. 39, 107-117.
17. A.-P. Zeng, K. Menzel, H. Biebl and W.-D. Deckwer (1995) Analysis of oscillation and hysteresis in continuous fermentation of glycerol by K. pneumoniae. In R.D. Schmid (ed.) Biochemical Engineering 3, pp 174-177, Kurz&Co, GmbH, Stuttgart, Germany.
16. A.-P. Zeng (1995) Effect of CO2 absorption on the measurement of CO2 evolution rate in aerobic and anaerobic continuous cultures. Appl. Microbiol. Biotechnol. 42: 688-691.
1994
15. T.-G. Byun, A.-P. Zeng and W.-D. Deckwer (1994) Reactor comparison and scale-up for the microaerobic production of 2,3-butanediol by Enterobacter aerogenes at constant oxygen transfer rate. Bioprocess Eng. 11: 167-175.
14. A.-P. Zeng, T.-G. Byun, C. Posten and W.-D. Deckwer (1994) Use of the respiratory quotient as a control parameter for optimum oxygen supply and scale-up of 2,3-butanediol production under microaerobic conditions. Biotechnol. Bioeng. 44: 1107-1114.
C. Wittmann, A.-P. Zeng and W.-D. Deckwer (1994) Minimal nutrient requirement for growth of Mycobacterium chlorophenolicus. Biotechnol. Lett. 16 (10): 1103-1106.
13. A.-P. Zeng, A. Roß, H. Biebl, C. Tag, B. Günzel and W.-D. Deckwer (1994) Multiple product inhibition and growth modeling of Clostridium butyricum and Klebsiella pneumoniae in glycerol fermentation. Biotechnol. Bioeng. 44: 44: 902-911.
12. B. O. Solomoon, A.-P. Zeng, H. Biebl, A.O. Ejiofor, C. Posten and W.-D. Deckwer (1994) Effects of substrate limitation on product distribution and H2/CO2 ratio in Klebsiella pneumoniae during anaerobic fermentation of glycerol. Appl. Microbiol. Biotechnol. 42: 222-226.
11. A.-P. Zeng and W.-D. Deckwer (1994) Pathway analysis of oxygen utilization and tricarboxylic acid cycle activity in Saccharomyces cerevisiae growing on glucose. J. Biotechnol. 37: 67-77.
10. A.-P. Zeng, P. Ghosh and W.-D. Deckwer (1994) Bioenergetic concepts applied to the modelling of a microaerobic process. In T.K. Ghose (ed.) Process Computations in Biotechnology. Vol II. pp: 376-394, TATA McGraw-Hill, Bombay .
1993
9. A.-P. Zeng, H. Biebl, H. Schlieker and W.-D. Deckwer (1993) Pathway analysis of glycerol fermentation by Klebsiella pneumoniae: Regulation of reducing equivalent balance and product formation. Enzyme Microb. Technol. 15: 770-779.
1992
8. A.-P. Zeng and W.-D. Deckwer (1992) Utilization of the tricarboxylic acid cycle, a reactor design criterion for the microaerobic production of 2,3-butanediol. Biotechnol. Bioeng. 40: 1078 - 1084.
7. A.-P. Zeng, T.-G. Byun und W.-D. Deckwer (1992) Die Ausnutzung des Tricarbonsäurezyklus: Eine wichtige Kenngröße zur Führung mikroaerober Prozesse. Chem.-Ing.-Tech. 64, 731-734.
1991
6. A.-P. Zeng, H. Biebl and W.-D. Deckwer (1991) Production of 2,3-butanediol in a membrane bioreactor with cell recycle. Appl. Microbiol. Biotechnol.34: 463-468.
5. A.-P. Zeng and W.-D. Deckwer (1991) A model for multiproduct-inhibited growth of Enterobacter aerogenes in 2,3-butanediol fermentation. Appl. Microbiol. Biotechnol. 35: 1-3.
4. A.-P. Zeng, T.G. Byun and W.-D. Deckwer (1991) On-line estimation of viable biomass of a microaerobic culture from exit gas analysis. Biotechnol. Techniques, 5(4): 247 - 250.
1990
3. A.-P. Zeng, A. Ross and W.-D. Deckwer (1990) A method to estimate the efficiency of oxidative phosphorylation and biomass yield from ATP of a facultative anaerobe in continuous culture. Biotechnol. Bioeng. 36: 965-969.
2. A.-P. Zeng, H. Biebl and W.-D. Deckwer (1990) 2,3-Butanediol production by Enterobacter aerogenes in continuous culture: role of oxygen supply. Appl. Microbiol. Biotechnol. 33: 264-268.
1. A.-P. Zeng, H. Biebl and W.-D. Deckwer (1990) Effect of pH and acetic acid on growth and 2,3-butanediol production of Enterobacter aerogenes in continuous culture. Appl. Microbiol. Biotechnol. 33: 485-489.
B. Books/Monographs/Theses
4. K. Schügerl and A.-P. Zeng (Eds.) (2002) Tools and Applications of Biochemical Engineering Science. Volume 74. Advances in Biochemical Engineering/Biotechnology. Springer-Verlag, Heidelberg.
3. Habilitationschrift (2000) Quantitative Zellphysiologie, Metabolic Engineering und Modellierung der Glycerinfermentation zu 1,3-Propandiol. Technische Universität Braunschweig.
2. A.-P. Zeng (1999) Sections Upstream Processing, Products and Processes (over 50 pages) in the Encyclopaedia "Römpp Lexikon Biotechnologie/Gentechnik", 2nd Edition, (Eds.) W.-D. Deckwer, A. Pühler, R.D Schmid, Thieme Verlag, Stuttgart.
1. Ph.D. Thesis (1990) Mikrobielle Produktion von 2,3-Butandiol durch Enterobacter aerogenes in kontinuierlicher Kultur: Quantitative Analyse und Prozessoptimierung. Technische Universität Braunschweig.
C. Proceedings and extended conference abstracts
1. B. Kumar, M. D'Silva and A.-P. Zeng (2007) Modularity analysis of integrated molecular networks of Escherichia coli. Proceedings of the 2nd. Conference Foundations of systems Biology in Engineering. Stuttgart, Germany. Pp. 89-94.
2. Bharani Kumar, Hong-Wu Ma and>A.-P. Zeng (2005) An integrated interaction network of Escherichia Coli. Proceedings FOSBE 2005 (Foundations of systems Biology in Engineering), University of California , Santa Barbara, August 7-10. pp 107-110.
3. A.-P. Zeng , Sun J, Wang W, Hartlep M, Deckwer WD.: Use of genomic, proteomic and metabolic data and mathematic modeling for a system analysis of glycerol bioconversion to 1,3-propanediol . In Proceedings of 3rd International Conference on Systems Biology. E. Aurell, J. Elf and J. Jeppsson, editors. Karolinska Institutet, Stockholm. 2002: 54-55.
4. W. Wang, J. Sun, M. Hartlep, A.-P. Zeng und W.-D. Deckwer (2002) Proteomics und Bioinformatik-Tools zur Prozessanalyse der 1,3-Propandiolproduktion in Klebsiella pneumoniae. Chem.-Ing. Tech. 74, 704.
5. M. Hartlep und A.-P. Zeng (2002) Fedbatch-Verfahren für die mikrobielle Herstellung von 1,3-Propandiol in Klebsiella pneumoniae und Clostridium butyricum. Chem.-Ing. Tech. 74, 663.
6. J.-X. Bi, C. Beer, M. Wirth und A.-P. Zeng (2002) Entwicklung und dynamische Analyse von GFP-Expressionsystemen als Biomarker für die Genexpression in verschiedenen Animalzelllinien. Chem.-Ing. Tech. 74, 693.
7. W. Sabra, H. Ma, W. Wang, E.-J. Kim und A.-P. Zeng (2002) Rekonstruktion und Simulation des metabolischen Netzwerks von Pseudomonas aeruginosa für die Bildung von Virulenzfaktoren. Chem.-Ing. Tech. 74, 688.
8. A.-P. Zeng , Ma HW.: System structure analysis of metabolic networks constructed from genome data. In Proceedings of 3rd International Conference on Systems Biology. E. Aurell, J. Elf and J. Jeppsson, editors. Karolinska Institutet, Stockholm. 2002: 238-239.
9. Sun, J, van den Heuvel, J and A.-P. Zeng (2001) Reconstruction of metabolic and regulatory networks of Klebsiella pneumoniae from genome data. Proceedings of the German Conference on Bioinformatics. E. Wingender, R. Hofestädt and I. Liebich (Eds.), Braunschweig, pp: 227-228.
10. K. Jung, A.-P. Zeng and W.-D. Deckwer (2000) Physiologische und enzymatische Charakterisierung der 1,3-Propandiol-Gewinnung aus Glycerin mit Clostridium butyricum. In: Schriftenreihe " Nachwachsende Rohstoffe" Band 15: Biokonversion nachwachsender Rohstoffe. Landwirtschaftsverlag, Münster. pp: 244-252.
11. J. Modak, W.-D. Deckwer and A.-P. Zeng (2000) System Dynamic Behavior of Eucaryotic Multienzyme Pyruvate Dehydrogenase Complex under In Vivo Conditions. Proceedings of the First International Conference of Systems Biology, 14-16 November 2000, Tokyo .
12. A.-P. Zeng and W.-D. Deckwer (1997) Recent progress in the study of Stoichiometry, Kinetics and Regulation of Metabolism and Growth of Animal Cell Cultures. In: Z. Shen, F. Ouyang, J.T. Yu and Z.A. Cao (eds.) Biochemical Engineering: Marching toward the Century of Biotechnoilogy.Tsinghua University Press, Beijing . 146-152.
13. A.-P. Zeng , K. Menzel, K. Ahrens, H. Biebl, J. van den Heuvel and W.-D. Deckwer (1997) Quantification of metabolic pathways and fluxes for metabolic engineering of glycerol conversion to 1,3-propanediol. In: Z. Shen, F. Ouyang, J.T. Yu and Z.A. Cao (eds.) Biochemical Engineering: Marching toward the Century of Biotechnoilogy.Tsinghua University Press, Beijing . 267-271.
14. H. Biebl and A.-P. Zeng (1995) Role of pH and limiting factors in the glycerol fermentation of Klebsiella pneumoniae. Proceedings of Ninth Forum for Applied Biotechnology. Gent , Belgium , September 27-29, 1995 . pp 1927-1932.
15. A.-P. Zeng , R. Wagner, V. Jäger, B. Anspach, U. Rinas and W.-D. Deckwer (1994) Integrated bioprocess development. In: Teo, W.K., Yap , M.G.S. and Oh, S.K.W. (eds.) Better living through innovative biochemical engineering. Continental Press , Singapore : 364-368.
16. A.-P. Zeng , A. Ross and W.-D. Deckwer (1990) A method to estimate the P/O ratio and YATP of a facultative anaerobe in continuous culture. In: Reuss/Knackmuss/Chmiel/Gilles (eds.) Biochemical Engineering - Stuttgart, Gustav Fischer Verlag. 1990, pp: 381-384.